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The Stewardship Science Academic Alliances (SSAA) Program was established in 2002 to support state-of-the-art research at U.S. academic institutions in areas of fundamental physical science and technology of relevance to the SSP mission. The SSAA Program provides the research experience necessary to maintain a cadre of trained scientists and engineers at U.S. universities to meet the nation’s current and future SSP needs, with a focus on those areas not supported by other federal agencies. It supports the DOE/NNSA’s priorities both to address the workforce specific needs in science, technology, engineering, and mathematics and to support the next generation of professionals who will meet those needs. The Office of Research, Development, Test, and Evaluation announce their interest in receiving applications for new or renewal financial assistance awards for research grants in the SSAA Program. Researchers seeking renewals of their current SSAA grant should apply to this FOA. The research areas of interest in the SSAA Program for this announcement are: properties of materials under extreme conditions and energetic environments; hydrodynamics, instabilities and hydrosonics; low energy nuclear science; and radiochemistry. The DOE/NNSA will consider applications for university-led research which can address one or more of the fundamental areas of physical sciences and engineering outlined below. Proposals should have an appropriate balance between advancing theory and understanding, simulation, and experimental efforts, and be of relevance to the NNSA Defense Program’s stockpile stewardship mission. Proposals that advance theory and physical modeling should have a strong, demonstrable connection to experimental efforts.