This Sources Sought is to determine if any SDVOB s are capable of providing the following: Oxycodone and Buprenorphine Reagents and Supplies Background. Service: Pathology and Laboratory Medicine Service, Core Laboratory Buprenorphine is a semi-synthetic opioid analgesic derived from thebaine, a component of opium. Buprenorphine resembles morphine structurally but has both antagonist and agonist properties.2 Buprenorphine has a longer duration of action than morphine and can be administered sublingually as an analgesic. Subutex®, a higher dose buprenorphine formulation, is widely used in Europe and elsewhere as a substitution treatment for opiate addiction.3-5 Recently, the FDA has approved the use of Subutex and Suboxone® containing buprenorphine as active drug, for the treatment of opiate dependence in the US. Oxycodone is a semi-synthetic opioid prescribed for pain management in patients with moderate to severe pain. It is similar to codeine and morphine in its analgesic properties but it is more potent than morphine and has higher dependence potential. The drug oxycodone is supplied as OxyContin® (Oxycodone HCl) or in combination with aspirin (Percodan®) or acetaminophen (Percocet®).1 Drug abusers crush the pills into powder and snort them for faster effect which may result in a potentially fatal outcome. Microgenics oxycodone and buprenorphine testing with urine specimens is FDA and manufacturer approved to be used with Beckman Coulter analyzers. Materials will be shipped within 3 business days of ordering. The Chemistry Quality Assurance technologist (Kristi Roche) and Supervisor (Erin Palmer) will be placing the order. All deliveries will be made to the dock area at Pittsburgh HCS, University Drive division. Monthly updates of materials shipped from the vendor will be sent via email to the Core Laboratory contact at VA Pittsburgh. Printed MSDS/SDS will be available upon request. Continuing educational opportunities will be offered by the contractor. Electronic copies of procedures will be provided on disc. Freight charges will be the responsibility of the contractor. Salient Characteristics: Description of Supplies Annual Quantity Unit Oxycodone reagent kit (mfr# 100248) 156 kit Buprenorphine reagent kit (mfr# 100240) 108 kit Oxycodone calibrator, 300 ng/mL (mfr# 100251) 12 kit Oxycodone calibrator, 1000ng/mL (mfr# 100253) 12 kit Buprenorphine calibrator, 5 ng/mL (mfr# 100242) 12 kit Buprenorphine calibrator, 75 ng/mL (mfr# 100245) 12 kit Oxycodone control kit (mfr# 100255) 24 kit Buprenorphine control kit (mfr# 100246) 12 kit Specific Tasks: When the products are received and the lot# and expiration dates for each item are logged and quality control reactivity and/or calibration verification is confirmed, the materials may be used for clinical testing. END

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