ITEM NO 0001 QUANTITY 2 UNIT Each UNIT PRICE ______________ AUTOMATED SATELLITE WORK STATIONFFPTwo Automated Satellite Chromosome Aberration Analysis Stations along with accessories to work in conjunction with a High Throughput Metaphase Finding and Scoring System for chromosome aberration analysis.The Automated Satellite Chromosome Aberration Analysis Stations work in conjunction with a High throughput Metaphase Finding System to further enhance sample analysis throughput. The microscope stage co-ordinates of automatically searched metaphase spreads using a High Throughput Metaphase Finding System, are digitally transferred to the Automated Satellite Chromosome Aberration Analysis Stations for rapid relocation for analysis by several Technicians. The equipment consists of a satellite work station with a computer, a bionocular high quality research microscope such as Olympus BX41 or equivalent, single slide automated stage with autofocus utility, a firewire camera, and automated bright field scoring and annotating software. Specifications: Automated Satellite Workstation: - 3.2GHz Pentium4 Computer, 512 MbRAM, 120GHD (or above) - 19" FIat LCD Monitor (or above) - DVDRW/CDRWith recorder - High quality binocular research microscope (Olympus BX 41 or equivalent) - 5 Mpixel Color Firewire Camera - Single Slide Automated Stage and Focus - Metaphase Finding and Scoring Software - Automated Satellite Scoring Software for Semi-Automated Scoring and Annotation All Satellites should have the following capabilities: - Semi-Automated Scoring and Annotation for the following assays - Chromosome Aberration Analysis - Sister Chromatid Exchange Analysis - Dicentric Assay Analysis - Mitotic Index Measurements Reviewing and Reporting Software: - Software only review station. - Review High Magnification Photos of each spread - Review Annotation Images - Score from Photos - Generate Reports Automated Metaphase Location Software: - Automated metaphase spread location on samples prepared from human peripheral blood lymphocyte cultures to minimize man-hour requirements for bright field chromosome aberration analysis. - Saves postage stamp image of each spread for rapid user review. - Automatically locates spreads under low power and relocates spreads at high power for user evaluation. - Adaptive Background Correction provides automated adjustment for variation in staining - Preloaded Search Algorithms for different preparations - Spread Location Algorithm - User Modifiable Spread Location Parameters for different preparations - Automated Statistical Analysis and Report Generation - Data Review, Visualization, and Reporting capabilities - GLP Compliance Support - Provides thru-camera light metering for easy setup of microscope illumination - User-Adjustable parameters for spread quality control - Precise scanning and relocation of spreads Semi Automated Scoring and Annotation: - Digital transfer of slide co-ordinates from the High Throughput Metaphase Finder - Ability to "check out" single slide or multiple slides for scoring. - Permanently lock study to prevent further changes to the experiment data for all slides. - System Security limits access to unauthorized users. - Generates summary reports and statistics (chi-square, t-test) for the entire experiment - Automated Statistical Analysis and Report Generation Eliminates transcription errors. - Data Review, Visualization and Reporting - GLP Compliance Support - Semi-Automated Annotation function - Automatically relocates spread on slide for scoring under high magnification. - Should be able to use as an automated one-slide Metaphase Finding System- Metaphase spreads from the most recently reviewed or scanned slide are displayed. - Automatically relocates spread on slide for scoring under high magnification - Photo of metaphase spread at high magnification for later review and documentation - Rapidly enter aberration data using software spreadsheets NET AMT _____________ ITEM NO 0002 QUANTITY 2 UNIT Each UNIT PRICE _____________ REVIEWING AND REPORTING SOFTWARE: - Software only review station. - Review High Magnification Photos of each spread - Review Annotation Images - Score from Photos - Generate Reports Automated Metaphase Location Software: - Automated metaphase spread location on samples prepared from human peripheral blood lymphocyte cultures to minimize man-hour requirements for chromosome aberration analysis. - Saves postage stamp image of each spread for rapid user review. - Automatically locates spreads under low power and relocates spreads at high power for user evaluation. - Adaptive Background Correction provides automated adjustment for variation in staining - Preloaded Search Algorithms for different preparations - Spread Location Algorithm - User Modifiable Spread Location Parameters for different preparations - Automated Statistical Analysis and Report Generation - Data Review, Visualization, and Reporting capabilities - GLP Compliance Support - Provides thru-camera light metering for easy setup of microscope illumination - User-Adjustable parameters for spread quality control - Precise scanning and relocation of spreads Semi Automated Scoring and Annotation: - Digital transfer of slide co-ordinates from the High Throughput Metaphase Finder - Ability to "check out" single slide or multiple slides for scoring. - Permanently lock study to prevent further changes to the experiment data for all slides. - System Security limits access to unauthorized users. - Generates summary reports and statistics (chi-square, t-test) for the entire experiment - Automated Statistical Analysis and Report Generation Eliminates transcription errors. - Data Review, Visualization and Reporting - GLP Compliance Support - Semi-Automated Annotation function - Automatically relocates spread on slide for scoring under high magnification. - Should be able to use as an automated one-slide Metaphase Finding System - Metaphase spreads from the most recently reviewed or scanned slide are displayed. - Automatically relocates spread on slide for scoring under high magnification - Photo of metaphase spread at high magnification for later review and documentation - Rapidly enter aberration data using software spreadsheets NET AMT _____________ ITEM NO 0003 QUANTITY 3 UNIT Each UNIT PRICE ____________ METAPHASE VIBRATION FREE TABLES TECHNICAL SPECIFICATIONS: Isolation Performance @ 5Hz:70-85% @ 10 Hz: 90% Natural Frequency 1.9-2.6 Hz Isolation Method Air suspension Air Supply Requirements Manual Hand Pump Leveling Manual Top Surface Standard FH-Steel laminated with vibration reducing sheet (Specify 'V' after the part number) Brushed Stainless Steel with mounting holes M6 or 1/4-20 (Specify 'FH' plus tap size and spacing i.e. DT-6050 A FH ¼-20 x 1) Air Pressure Requirements 3-7 kg/cm2 (20-50psi) Accessories included Hand pump and air valve adjuster SIZES / WEIGHTS Quantity (2) (1) Load Capacity 100 kg 100 kg (221 lb.) (221 lb.) Top Plate Size 600x500 800x600 (23.6x19.6) (31.5x23.6)Overall 692x540x168 892x640x168 (25.7x22.6x3.1) (35.1x25.2x3.1) NET AMT _________________ ITEM NO 0004 QUANTITY 3 UNIT Each UNIT PRICE __________ UNINTERRUPTABLE POWER SUPPLY Minimum Requirements: $150,000 Lifetime Equipment Protection Policy plus a 2-year repair or replace warranty. Product Description: - USB - UPS - 1500 VA - UPS battery - lead acid - Output connector(s) 8 x power NEMA 5-15 - Output Voltage AC 120 V - Input Voltage AC 120 V - Battery Form Factor Plug-in module - Average Run Time 6.7 min at full load - Power Provided 1500 VA - Device Type UPS - Battery UPS battery - lead acid - Warranty 2 years warranty - Form Factor External Ports/Connectors: - Output Connections: (8) NEMA 5-15R outlets - Input Connection Type: NEMA 5-15P - Cord Length: 6 ft. - Communications & Management: (1) DB9 interface port (RS-232) (1) SmartSlot card interface (1) USB port Power Notes: - Output power capacity: 1440VA - Output power capacity: 980 Watts - Max. Configurable Power: 1440VA - Max Configurable Power: 980 Watts - Nominal output voltage: 120V - Waveform Type: Sinewave - Nominal Input Voltage: 120V - Input Frequency: 50/60Hz +/- 3Hz (auto-sensing) - Input Voltage Range for Main Operations: 82 - 144V - Input Voltage Adjustable Range for Main Operations: 75 - 154V Battery Notes: - Typical backup time at half load: 22.8 minutes - Battery type: Maintenance-free sealed Lead-Acid battery with suspended electrolyte (leak-proof) - Typical recharge time: 3 hrs.Surge Protection and Filtering: Surge energy rating: 320 joules - Filtering: Full time multi-pole noise filtering : 0.3% IEEE surge let-through : zero clamping response time : meets UL 1449 NET AMT ________________ ITEM NO 0005 QUANTITY 1 UNIT Each UNIT PRICE __________ METAPHASE FINDER & SCORING SYSTEM Equipment, Accessories, and Supplies: A High Throughput Bright Field Metaphase Finding and Scoring System for chromosome aberration analysis. Summary of Description of the Item: The Highthroughput Metaphase Finding System automatically locates metaphase spreads, obtained from human peripheral blood lymphocyte cultures, on microscope slides under a brightfield microscops and relocates metaphase spreads for user review and aberration analysis. This High Throughput Metaphase Finding System consists of a Pentium Computer (3.2 GHz), a firewire camera, a highquality microscope, an automated stage with autofocus, and slide vacuum delivery robotics. The computer is loaded with a automated metaphase finding software, an interactive automated scoring and annotation software for different types of cytogenetic applications. Specifications: High Throughput Metaphase Finding and Scoring System Hardware: - 3.2GHz Pentium4 Computer, 512 MbRAM, 120GHD - 19" FIatLCD Monitor t. - DVDRW/CDRW recorder - 5 Mpixel Color Firewire Camera - BX41 BrightField Microscope - Single Slide Automated Stage and Focus 150 Slide Vacuum Delivery Robotics Software Applications: - Automated Metaphase Location Software - Semi-Automated Scoring and Annotation - Dicentric Assay Scoring - Chromosome Aberration Scoring - Sister Chromatic Exchange Scoring - Mitotic Index Mpixel Color Firewire Camera Sensor: - Type : 2/3" ICX282AQ progressive scan interline - CCD color (Bayer Mosaic), 5.0 megapixels - Resolution : 2580 x 1944 active pixels - Pixel Size :3.4 um x 3.4 um - Optical Interface : C-mount, 2/3" optical format for microscope or camera lens - Digital Output : 8/10-bit digitization, 30-bit color digitization - Readout Frequency : 20 MHz 8-bit, 10 MHz 10-bit - Frame Rate : 3.5 fps full resolution 8-bit, higher speeds with binning and ROI functions Computerized Control of Camera Function: - Exposure Control : 1.6 milliseconds to 17.9 minutes in 1 microsecond increments - Binning Modes : 2x2, 3x3, and 4x4 with full color images - Shutter Control: Electronic Shutter - ROI: Image size and position control BrightField Microscope Features (Olympus BX41 or equivalent): - Designed for performing in bright field light - Bright 12V/100W halogen light source for transmitted light viewing - Built-in filters (two neutral density and one daylight balancing) for efficient photomicrography - Automated inward-facing five-position nosepiece for easy objective rotation - High-sensitivity fine focusing knob (adjustment gradations: 1 um) - Illuminator Built-in Kohler illumination for transmitted light - Condenser (Numerical aperture 1.1), 4x-100x - 10x, 100x dry plan achromatic objectives - 0.5x C-Mount Adapter Single Slide Automated Stage and Focus: - XY motion: Nanomotors capable of 5 um steps - Focus: Positioning capable of 0.02 um steps - Preloaded search patterns - Focus Algorithms Slide Vacuum Delivery Robotics capable of handling over 100 slides: - Automatically delivers and retrieves sequentially ordered slides for unattended high-throughput microscopic analysis. - Digitally controlled vacuum pick-up unit. - Up to 50 slides are stacked in each storage bin, with a maximum capacity of over 100 slides. - Small laboratory bench top footprint. - Must handle regular 1 "x3" microscope slides, and should be adaptable to larger slide formats (2"x3", 4"x3"). Automated Metaphase Location Software: - Automated metaphase spread location on samples prepared from human peripheral blood lymphocyte cultures to minimize man-hour requirements for chromosome aberration analysis. - Saves postage stamp image of each spread for rapid user review. - Automatically locates spreads under low power and relocates spreads at high power for user evaluation. - Adaptive Background Correction provides automated adjustment for variation in staining - Preloaded Search Algorithms for different preparations - Spread Location Algorithm - User Modifiable Spread Location Parameters for different preparations - Automated Statistical Analysis and Report Generation - Data Review, Visualization, and Reporting capabilities - GLP Compliance Support - Provides thru-camera light metering for easy setup of microscope illumination - User-Adjustable parameters for spread quality control - Precise scanning and relocation of spreads - Semi Automated Scoring and Annotation: - Semi-Automated Scoring and Annotation ability for the following assays - Chromosome Aberration Analysis for genetic toxicology testing of test compounds - Analysis of Sister Chromatic Exchanges - Analysis of radiation induced dicentrics - Measurement of Mitotic Index - Metaphase spreads from the most recently reviewed or scanned slide are displayed. - Automatically relocates spread on slide for scoring under high magnification - Photo of metaphase spread at high magnification for later review and documentation - Rapidly enter aberration data using software spreadsheets - Ability to permanently lock study to prevent further changes to the experimental data for all slides. - System Security limits access to unauthorized users. - Generates summary reports and statistics (chi-square, t-test) for the entire experiment Net Amount ____________________

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