The Food and Drug Administration intends to award a purchase order on a sole source non-competitive basis to Affymetrix Inc. 3420 Central Expressway, Santa Clara, California. FDA will purchase Custom E. Coli Genechip Microarrays. The Genechip microarrays are to be utilized with an existing integrated Affymetrix Genechip scanner 3000 and Fluidics 450s systems. The following instrument specifications are met only by Affyrmetrix and no other known instrument in the market. The arrays are able to be read and utilized by the Affymetrix GeneChip Scanner 3000 System which is currently being utilized by our FDA laboratory. The GeneChip Scanner 3000 System is a fully integrated platform for conducting research using the Affymetrix GeneChip? Custom Genotyping assays and GeneChip probe arrays. The system includes the GeneChip Scanner 3000, Fluidics Station 450s, Hybridization Oven 640, a powerful computer workstation with dual Xeon processors loaded with GeneChip Operating Software. The arrays are high-density probe arrays capable of performing quantitative and simultaneous monitoring of thousands of genes. The arrays are able to accommodate at least 22,000 unique E.coli genes and 1,000 control sequences (23,000 total probe sets). Each of the gene sequence represented on the arrays have 11 perfectly matched 25-mer probes as well as 11 mismatch 25-mer probes in order to estimate nonspecific hybridization. This results in an array capable of accommodating >500,000 individual features. Additionally, the sizes of each of these features are 11 microns. The arrays contain the following hybridization controls: bioB, bioC, bioD and cre., and a normalization control set of 100 probe sets. The microarrays are unique and are available solely from Affymetrix. FDA intends to make an award immediately after the response date of this notice. This is not a request for quotes; however sources may submit descriptive literature, fully documenting their capabilities, which will be considered by the agency. A determination to compete this procurement based on response(s) to this notice is solely within the discretion of the Government. The non-competitive award will be made in accordance with FAR Part 12 Acquisition of Commercial Items and FAR Part 13 Simplified Acquisition Procedures.

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