This notice is a combined synopsis/solicitation, Notice of Intent. The Government intends to negotiate on a sole source basis with Affymetrix, for Custom Gene Chips, in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are not being requested and a written solicitation will not be issued. Submit offers on NOI-RML #6007. The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-08 dated 1/5/06, and 2005-07(b) dated 2/2/06. This acquisition will be processed under Simplified Acquisition Procedures (SAP) and is not a Small Business Set-Aside. The North American Industry Classification System (NAICS) code for this procurement is 541710 and the small business size is 500. SCHEDULE: The Rocky Mountain Laboratories, (RML),performs basic research contributing to the development of diagnostic reagents, therapeutics and vaccines against human bacterial pathogens. Purchase of 55(fifty-five) Affymetrix microarray Mouse genome chips containing oligonucleotide sequences representing the mouse genome will assist towards achieving those goals. The RTS has a need to purchase Affymetrix GCS 3000 workstation-compatible Mouse genome chips for protocol optimization, development and use in RML microarray experiments. This is a 6(six) week, one time work effort, where the final product will be 55(fifty-five) Mouse genome expression arrays containing oligo pairs at high density, specific to all known and identified Mouse genes. The contractor shall have the appropriate proprietary rights to design and manufacture these chemical reagent, consumable chips. These chips shall be compatible with the Affymetrix fluidics and hybridization station and scanner. The design and manufacturing process of this mouse gene chip is wholly patented and owned by Affymetrix. The chip shall be high density, at 106 per cm2 or greater (USPNos. 5445934 and 5744305). The Mouse GeneChip® shall be made by photolithography manufacturing technology (USPNos. 5424186, 5510270), developed solely by Affymetrix. The mouse GeneChip® probe array must enable identification of 2-fold or greater levels of change in expression levels, and detection of as little as 1 mRNA transcript in a complex mixture of 100,000. The GeneChip® probe array must contain multiple unique probes designed to be Perfect Match (PM), 25-mer oligonucleotide probe pairs, to represent each mRNA transcript (full length gene) tested, and multiple probes designed to be Mis-Match (MM), to enable calibration of non-specific hybridization data (USPNos.5527681). Additional control sequences (yeast and commensal) must also be available on the chip for hybridization control, and housekeeping gene analysis. The probe selection strategy shall be based upon a probe design database (USPNos. 6188783) and shall be able to distinguish between highly homologous sequences and those of closely related gene families. The Mouse GeneChip® probe array shall be housed in a fixed volume reaction chamber (USPNos. 5945334, 6140044) providing automated and consistent hybridization of samples to the array. We will process the chips on the RML Affymetrix GeneArray® Scanner, Fluidics Station, 640 Hybridization Oven, Micro Array Suite/Data Mining Tool (USPNos. 5871928, 6040138, 6197506), MicroDB, and LIMS software database. No other photolithography-based chip, apart from those purchased from Affymetrix is compatible with the Affymetrix system in place at the RML. FOB Point shall be Destination, Hamilton, MT. Inside delivery shall be six(6)weeks after receipt of the order by Affymetrix. Delivery location is Rocky Mountain Laboratories, 903 S. 4th Street, Hamilton, MT. The following FAR provisions and clauses apply to this acquisition: (B)(1) By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the CCR database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation; By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall have posted their FAR 52.212-3 Offerors Representations and Certifications Commercial Items at website http://orca.bpn.gov; 52.212-1 Instructions to Offerors Commercial; FAR52.212-2 Evaluation Commercial Items; FAR 52.212-4 Contract Terms and Conditions Commercial Items; FAR 52-212.5 Contract Terms and Conditions Required to Implement Statues or Executive Orders Commercial Items. FAR52.246-2 Inspection of Supplies-Fixed Price. Award will be based on the capability of the item offered to meet the above stated salient characteristics, delivery, price and past performance. Offers may be mailed to Julienne Keiser at Rocky Mountain Laboratories, 903 S. 4th Street, Hamilton, Mt 59840, or faxed to the POC indicated above (Fax - 406-363-9376), or e-mailed at ([email protected]). Offers must be submitted not later than 4:30 PM (MDST), 2/22/06. Copies of the above-referenced clauses are available upon request, either by telephone or fax, or are available at http://www.arnet.gov/far/current/html/52_000-107.html. All responsible sources may submit an offer that will be considered by this Agency.

Bid Protests Not Available