The National Institute of Environmental Health Sciences solicits proposals on a restricted basis from small businesses for managerial, technical, and clerical support for a study of environmental and genetic risk factors for breast cancer. Target recruitment is 50,000 women throughout the United States. Eligibility criteria - (1) ages 35-74, (2) have a sister who has had breast cancer (3) have never had breast cancer themselves. The expected recruitment period is up to forth-eight (48) months, with followup to continue for ten (10) years. Major activities include the following: recruitment continuity for transition from current pilot activities eligibility, screening, and enrollment data collection Collection, transportation, processing, and data management for biological samples (blood samples, urine, and toenails) and environmental samples (household dust and water) confidentiality and human subjects protections data management task analysis quality assurance/quality control The estimated release date for the solicitation is mid February. The estimated receipt date for proposals is early April. Electronic versions of the RFP will be available at http://www.niehs.nih.gov/dert/rcb/rfp.htm. All eligible responsible sources may submit a proposal which shall be considered. See note No. 1.

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