The National Institute of Environmental Health Sciences is seeking Offerors who have the capability to test approximately fifty (50) chemicals per year up to ten (10) years for somatic cell genetic effects in animals, usually rats and/or mice. Endpoints which will be assessed include:Task 1 - Micronuclei in bone marrow and/or other tissues (e.g. lung, spleen, peripheral lymphocytes). Animals will be treated in the contract laboratory for these studies. Task 2 - Micronuclei in peripheral erythrocytes from sub-chronic studies. Animals will be treated in other laboratories and cells shipped to the contract laboratory for micronucleus scoring. Task 3 - Centromeric probe analysis of micronuclei Task 4 - Single cell gel electrophoresis assays of various tissues Task 5 - Analysis of genetic toxicity information. New technology has automated the process of counting the number of micronuclei cells on slides and therefore a Flow Cytometer is required of the Offeror to perform this project. The Government estimates that Tasks one (1) to four (4) will require approximately six (6) to seven (7) person-years per year. Task five (5) will require one (1) person-year per year and this position is will be on site at the NIEHS and office space, equipment, and materials will be provided by the government. The period of performance will be ten (10) years. The North American Industry Classification Code (NAICS) is 541710 and the small size standard is 500 employees or less. See numbered Notes 1 and 26.

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