The Preclinical Research and Development Branch (PRDB), Vaccine and Prevention Research Program (VPRP), Division of AIDS (DAIDS), has a requirement for vaccine and non-vaccine prevention modelity production, non-clinical testing and regulatory document compilation. It is anticipated that one contract will be awarded for a period of five years. The development of vaccines to prevent the spread of HIV infection and assist biodefense (BD) efforts is among the NIAID’s highest priorities. Likewise, there is a critical need to promote the development of novel microbicides for prevention of sexual transmission of HIV, particularly in the absence of an effective, or even partially effective vaccine. In addition, vaccines administered to infected individuals have potential for inducing immune control of the infectious agent. While advances in immunology and molecular biology continue to offer an expanding array of approaches for the development of new products, there is limited capacity to move promising concepts through the development process. In order to supplement limited industry involvement in developing vaccines, microbicides, and other non-vaccine prevention modalities, the NIAID requires a nontraditional, proactive and developmentally oriented program to provide preclinical development support for promising candidates when such candidates emerge from investigator-initiated research studies. The NIAID will use a Master Contract for Preclinical Development to more rapidly and efficiently close development and production gaps. Directly or through subcontractors and/or consultants, this contract will function in the following five major areas: Project Management; Process Development and Production; Safety, Immunogenicity and Spectrum of Activity Testing; Regulatory Documentation; and Information Technology and Data Management. It is anticipated that a single cost reimbursement, completion type contract will be awarded for a period of five (5) years, beginning in April 2004. RFP NIH-NIAID-DAIDS-04-23 will be available electronically on or about April 7, 2003, and may be accessed through the NIAID Contract Management Branch (CMB) Home Page at http://www.niaid.nih.gov/contract --and will also be posted on FedBizOpps. Any responsible Offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. No collect calls will be accepted. Point of Contact Brenda Brooks, Contracting Officer, Phone 301-435-2765, Fax 301-402-0972, Email [email protected] - Jacqueline Holden, Senior Contracting Officer, Phone 301-496-7119, Fax 301-402-0972, Email [email protected]

Bid Protests Not Available