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There is only one drug that has been approved by the FDA for treatment of sickle cell disease. The drug is only partially successful, so there is an urgent need for addtional drugs. The Eaton group of 8 PhD scientists and one post-bac are working full time to discover an additional drug using a high throughput drug screen on intact sickle cells. The screen measures sickling times and judges the therapeutic potential of a candidate drug by its increase in sickling times, which is widely distributed because of the wide distribution of intracellular hemoglobin concentrations. The sickling time is enormously sensitive to the intracellular hemoglobin concentration, so knowing the distribution of intracellular concentrations, which is different for every patient, is critical for understanding the results of the screen. All hematology systems only measure the mean intracellular hemoglobin concentration, which is insufficient because of the wide and often bimodal distribution for sickle cells. Thus we require the entire distribution, which requires that the instrument measures and reports the intracellular hemoglobin concentration for each of the thousands of cells that are analyzed.
We urgently need an instrument that can measure the distribution of intracellular
hemoglobin concentrations. The Advia2120 Hematology System of Siemens
Healthineers is the only instrument capable of making these measurements. The Advia 2120 can do this because, unlike every other hematology instrument, it utilizes a dualangle light scattering method which allows determination of both volume and hemoglobin concentration of every cell. There is no competing instrument that has this capability.
The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the all the products and or services specified in this synopsis should submit a copy of their quotation to the below address or via email to [email protected]. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements. Quotations will be by September 21, 2017 before 10:00 am EST. via email or postal mail. The quotation must reference "Solicitation number" NICHD-17-186. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development - 6710B Rockledge Drive, Room MSC 1159A, Bethesda, MD 20892. Note: Fed Ex/Ups/other courier use 20817. Attention: Verne Griffin, by the date and time mentioned above.
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