This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD-16-162 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-89. The North American Industry Classification (NAICS) Code is 334516 and the business size standard is 1000. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to contract on a sole source basis with Bruker Biospin Corporation of Billerica, MA to procure the following item:
E5804200 E 580-AWG Arbitrary Waveform Generator:
Dual channel AWG
1.6 GS/sec
14 bit vertical resolution
System main frame
PCI bus
Air cooling units
Embedded control CPU
Frequency up conversion to X-Band
Operating range ±400 MHz at carrier
Xepr frontend implementation
Adaptation to Elexsys E 680 Spektrometer System
Feature definition for each pulse
Frequency
Chirp
Phase
Shape
Offset
Pulse overlap
User defined waveform
Run from tables and PulseSPEL implementation

Pulsed Q-band EPR spectroscopy, specifically double electron-electron resonance (DEER) experiments, permit accurate distance measurements to be made between pairs of spin labels attached to proteins and other macromolecules ranging from 20 to 100 Å. By engineering a variety of spin-label positions using site-directed mutagenesis to introduce surface exposed cysteine residues, a fairly large number of such distances can be obtained, thereby enabling one to quantitatively characterize conformational changes as well as subunit arrangements in multi-subunit proteins. Because EPR is not limited by molecular weight, this technique is applicable to proteins and other macromolecules ranging from a few kDa to many megadaltons. Currently our particular focus is on the use of pulsed EPR DEER spectroscopy to characterize the open-to-closed state conformational transition for the mature p66/p51 HIV-1 reverse transcriptase heterodimer associated with nucleic acid recognition and binding, and of the arrangement of domains and subunits within the p66/p66 homodimer precursor (prior to HIV-1 protease cleavage). The projects being investigated will be focused in the principal areas of research currently being undertaken in the Laboratory of Chemical Physics, NIDDK. Focus will be placed on a number of systems related to the structural biology of HIV-1, including Gag, capsid, protease, reverse transcriptase, integrase and gp41, as well as various host proteins relevant to the pathogenesis of AIDS. The initial work will focus on characterizing (a) the populations of homodimeric (p66/p66) and heterodimeric (p66/p51) states of HIV-1 reverse transcriptase, and open and closed conformations of the homo and heterodimers when free, bound to DNA and bound to various reverse transcriptase-directed anti-retroviral drugs; and (b) the overall arrangement of structural domains within the p66/p66 homodimer precursor of HIV-1 protease. The projects on HIV-1 reverse transcriptase are especially relevant to facilitating the development of new anti-retrovirals that target the precursor p66/p66 homodimer of HIV-1 reverse transcriptase, as well as improved anti-retroviral that target the mature p66/p51 homodimer.
The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302.
The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the product specified in this synopsis should submit a copy of their quotation to the below address or via email to [email protected]. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all of the foregoing requirements. Quotations will be due on September 8, 2016 before 11:00am EST. via email or postal mail. The quotation must reference "Solicitation number" NICHD-16-162. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development 6710B Rockledge Drive, Room 1155A, MSC 7000 Bethesda, MD 20892. Note: Fed Ex/Ups/other courier use 20817. Attention: Verne Griffin, by the date and time mentioned above. Any questions must be sent via email to [email protected] and must include solicitation# NICHD-16-162 in the subject line of email. Faxed copies/responses will not be accepted.
Note: In order to receive an award, contractor must be registered and have valid certification for all awards in the SAM database @www.sam.gov.

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