This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.
This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.
Background: The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The National Center for Advancing Translational Sciences (NCATS) is a translational science center that prides itself on its tremendously productive pipeline and is innovative in a number of ways. NCATS brings together a diverse range of scientists, including medicinal chemists, biologists, toxicologists, and engineers, in order to ultimately translate basic science into real products and services that help improve people's lives.
Hydroxynorketamine and analogs thereof are interest for NCATS for the potential treatment of a variety of mental illnesses. By synthesis and testing of selected analogs, NCATS hopes to better understand the mechanisms that underlie certain mental illnesses and potentially provide superior treatment options.

Purpose and Objectives: The purpose of this project is to obtain a custom synthesis of derivatives of hydroxynorketamine, which install a methyl group in the "5" position of the ring.
Contractor Requirements:
1. Contractor will synthesize the following compounds
a. (2R,5R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxy-5-methylcyclohexan-1-one
i. SMILES: O=C1[C@H](O)[C@H](C)CC[C@]1(C2=CC=CC=C2Cl)N
b. (2R,5S,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxy-5-methylcyclohexan-1-one
i. SMILES: O=C1[C@H](O)[C@@H](C)CC[C@]1(C2=CC=CC=C2Cl)N
c. (2R,5S,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxy-5-methylcyclohexan-1-one
i. SMILES: O=C1[C@@H](O)[C@@H](C)CC[C@]1(C2=CC=CC=C2Cl)N
d. (2R,5R,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxy-5-methylcyclohexan-1-one
i. SMILES: O=C1[C@@H](O)[C@H](C)CC[C@]1(C2=CC=CC=C2Cl)N
2. Contractor will provide 100 mg of each of these compounds
3. Compound purity will exceed 95%
4. Compound enantiomeric excess will exceed 95%

LEVEL OF EFFORT
Contractor will have 10+ years previous experience in the field of custom organic synthesis (small molecule).

GOVERNMENT RESPONSIBILITIES
Government will have the responsibility to review and approve the final report and analysis of the final delivered compounds. Government will not furnish property, facilities, workspace, computers, or other equipment. Contractor will not use federal facilities.

DELIVERY OR DELIVERABLES
In addition to the compounds, contractor will provide a final comprehensive report with synthesis, analytical data, and single crystal X-ray crystallization data:
1. The synthetic route utilized to provide the compounds
2. Analytical data including 1H NMR and LC-MS of the final compounds
3. Structural conformation by single crystal X-ray crystallography, with the associated data and data files.
REPORTING REQUIREMENTS
Contractor will provide monthly updates via email on the progress of the project, or more often as appropriate.

TRAVEL
N/A

KEY PERSONNEL
N/A

OTHER CONSIDERATIONS
Information System Security Plan:
N/A

Data Rights:
Data generated as a result of the synthesis will be the property of NCATS

Section 508-Electronic and Information Technology Standards:
N/A
Publications and Publicity:
Contractor will not publish the results of the work

Confidentiality of Information:
Contractor will keep the results of the work confidential.

Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.
The information submitted must be must be in an outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.
The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.
All responses (capability statements) sent in response to this Small Business Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted.
The response must be submitted to Stacey Polk, Contract Specialist at [email protected].
The response must be received no later than the closing date of this notice.
"Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work.
Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.
Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."

Bid Protests Not Available