The PEPFAR program in Botswana combines the talents of staff members and operational partners from the Department of State (DOS), the Centers for Disease Control and Prevention (CDC), the Health Resources and Services Administration (HRSA), the Department of Defense (DOD), the U.S. Agency for International Development (USAID), and the Peace Corps to implement an integrated HIV/AIDS program.  These entities come together to create a program that supports activities in Botswana, allowing for rapid, unprecedented expansion of programs and services.  This expansion takes into account expected inputs from the Global Fund, other donors, and the Government of Botswana (GoB) itself.   Differing perspectives, interests, and agendas of the diverse implementing partners  as well as  the scope, magnitude, and urgent focus on results of the PEPFAR program create unique challenges and opportunities.