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Chemists in the NIH/NIDDK Bethesda, MD have designed and synthesized a series of new molecules called cyclopentane peptide nucleic acids (cyPNAs). Some of these molecules are potential components for diagnostic kits to be used for the rapid detection of nucleic acids associated with diseases. The development of new diagnostic kits to signal the early stages of infections or cancers could be of great benefit to human health and thus to NIDDK's mission. To make cyPNAs and study their binding to nucleic acid sequences, it is essential to have the correct starting materials. The NIDDK lab has shown that the incorporation of trans-cyclopentanediamine into PNA backbones improves binding to target nucleic acid sequences. Our research on cyPNA development for the detection of nucleic acids associated with diseases therefore depends on the purchase of the chemicals in this order. These are the essential starting materials we must have for our research to continue. Substantial in vitro work has been done to select cyPNAs to move forward as probes for diseases, which has incurred substantial investment.
The objective of the research is to advance the testing of cyPNA as probes to signal the presence of infection or disease. To properly make cyPNA oligomers, the lab must have the correct building blocks that will be made from the materials to be purchased in this contract. The company must provide 100g each of (1S,2S)-trans-N-Boc- Tetrahydro-3,4-furandiamine and (1R,2R)-trans-N-Boc- Tetrahydro-3,4-furandiamine. These materials will be converted into the monomers needed to make cyPNA probes to target specific nucleic acids sequences associated with infection or disease. Results from each set of tests done are added to the file that will eventually be submitted for FDA approval as a new diagnostic test. The continuity of the project is enhanced by the use of as few CRO's as possible and only ones technically qualified to meet the specific needs of the research. This is a highly specific research-based purchase to acquire materials that are not commonly produced. These are synthetic materials that do not occur naturally and must be made using custom protocols.
TASKS AREAS
Independently, and not as an agent of the Government, the contractor shall perform all the detailed Task Areas listed below:
Task Area 1
Synthesize 100g each of (1S,2S)-trans-N-Boc-cyclopentanediamine and (1R,2R)-trans-N-Boc- Tetrahydro-3,4-furandiamine with purity equal or greater than 98% by NMR, and with enantiopurity greater than 99%ee. Any single contaminant to be less than 1.0% by weight.
Task Area 2
Deliver 100g each of (1S,2S)-trans-N-Boc- Tetrahydro-3,4-furandiamine and (1R,2R)-trans-N-Boc- Tetrahydro-3,4-furandiamine in a glass or plastic canister inside a protected shipping box or package to NIDDK investigator on NIH campus, Building 8, Room 404.
Task Area 3
Deliver each Certificate of Analysis to NIDDK Investigator.
Task Area 4
Deliver written details of synthesis as conducted including throughput, to make the compound, to NIDDK investigator.
PERIOD OF PERFORMANCE
Synthesis, analysis and delivery of Enantiomers of trans-N-Boc-1,2- Tetrahydro-3,4-furandiamine
100 g of each molecule
90 days from award of Contract
The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. The Government will make award based on Best Value.
Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract:
1. Name of Contracting Organization
2. Contract Number (for subcontracts provide the prime contract number and the subcontract number)
3. Contract Type
4. Total Contract Value
5. Description of Requirement
6. Contracting Officer's Name and Telephone Number
7. Program Manager's Name and Telephone Number
3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far.
Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below email address. Quotations will be due 11:00AM EST August 12, 2019. Offerors shall send the quotation/proposal to Verne Griffin at [email protected]. The quotation must reference Solicitation number RFQ-NICHD-19-176. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."
Faxed copies will not be accepted.