The laboratory of Circuits, Synapses, and Molecular Signaling (LCSMS) at National Institute of Neurological Disorders and Stroke (NINDS) uses cutting-edge imaging, physiological, and behavioral methods to investigate the relationship between human neurological disorders and brain function at the molecular, synaptic, cellular, and circuit levels. The laboratory requires an episcope imaging system with both brightfield and fluorescence imaging capabilities. The NINDS LCSMS requires an Epifluorescence Microscope to be used to capture high-quality images of fixed tissue or dispersed cells for ongoing studies investigating learning and memory, peripheral pain disorders, and neurodegenerative disease.