This Small Business Sources Sought Notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation or commitment by the Government. This notice is intended strictly for Market Research. The National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases is conducting a market survey to determine the availability and technical capability of qualified small business, veteran-owned small business, service-disabled veteran-owned small business or HUBZone small businesses capable of providing Ingenuity Variant Analysis.

Overview of Ingenuity Variant Analysis
Ingenuity Variant Analysis is a web--based application that helps us in studying Type 2 Diabetes to identify causal variants from Pima whole genome sequencing data. Ingenuity Variant Analysis combines analytical tools and integrated content to help rapidly identify and prioritize variants by drilling down to a small, targeted subset of variants based both upon published biological evidence and our knowledge of Type 2 Diabetes biology. With Variant Analysis, you can interrogate the variants from multiple biological perspectives, explore different biological hypotheses, and identify the most promising variants for follow-up.

Required Features:
• Pathway Analysis capabilities, including pathway diagrams with rapid one click access to supporting literature references.
• The ability to adjust filters to correspond to a new hypothesis simply by pointing and clicking, with results returned in seconds. This enables researchers to rapidly iterate on their hypotheses and get immediate results, speeding discovery.
• Scalable processing capacity provides the ability to analyze thousands of samples simultaneously. Ingenuity Variant Analysis has been demonstrated to support study sizes ranging from individuals and trios to thousands of samples in a single analysis
• Data and graphics can be exported to aid in manuscript preparation and publications
• Ability to create a stable URL that links an article to an analyzed data set to produce an online supplement that readers can use for free
• Support for HIPMand Safe Harbor compliance safeguards patient privacy.

The intended procurement will be classified under North American Industrial Classification (NAICS) code 511210 with a size standard of $38.5 Million. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. Capability statement must be received at the email address identified in this synopsis by 11:00 A.M. local time on August 1, 2016. Any questions regarding this announcement must be sent via email to [email protected] and must include solicitation NICHD-16-131 in the subject line of email.

This synopsis is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation. Confidentiality - No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)." PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov

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