The Centers for Disease Control and Prevention intends to issue a sole source purchase order to Government Scientific Source, Inc, 12351 Sunrise Valley Drive, Reston, VA 20191-3415 for purchase of multi-label detection microplate. The selected instrument must meet diverse assay development needs and be backwards compatible with existing assays and platforms. Needs include features such as multiple primary detection modes including UV-Vis absorbance (Abs), fluorescence intensity (FI), fluorescence polarization (FP), time-resolved fluorescence (TRF) and luminescence (Lum) with secondary detection modes wavelength selection tunable monochromator wavelength range (Absorbance) 200-1000 nm, a wavelength range (Fluorescence) 250-850 nm with bandwidth 4 nm. Absorbance 9 nm Excitation, 15 nm Emission for FI cuvettes. Capacity to provide Abs, FI, Lum in microplate formats of various sizes from 6-384 wells. Can read cuvettes and test tubes. Readings can be collected as either endpoint or kinetic reads. Can collect multiple wavelength per well to allow multiplexing and FRET analyses. Can collect selectable wavelength and luminescence readings as well as complete spectral scanning. Plates can be read from either the top or the bottom-reading for FI, TRF, Lum application. More complete specificiations: General Photometric Performance: Plate formats: 6, 12, 24, 48, 96, 384 wells, Light source: Xenon Flash Lamp (1 joule/flash), Detectors: 2 photomultiplier tubes, Shaker time: 0 to 999 seconds, Temp. control: 2¡ãC above ambient to 60¡ãC, Temp. uniformity: < 1¡ãC at 37¡ãC set point, Temp. accuracy: ¡À1¡ãC at 37¡ãC set point, Endpoint reading : All modes, Kinetic reading : All modes, Spectral scanning: All modes, Well scanning: Abs, FI, TRF, Lum; Absorbance Photometric Performance: Reading capabilities: Cuvette or microplate, Wavelength range: 200-1000 nm, Wavelength selection: Monochromator, tunable in 1.0 nm increments, Wavelength bandwidth: ¡Ü 4.0 nm, Wavelength accuracy: ¡À2.0 nm, Wavelength repeatability: ¡À0.2 nm, Photometric range: 0-4.0 OD, Photometric resolution: 0.001 OD, Photometric accuracy (microplate): < ¡À0.006 OD ¡À1.0%, 0-2 OD, Photometric accuracy (cuvette): < ¡À0.005 OD ¡À1.0%, 0-2 OD, Photometric precision: < ¡À0.003 OD ¡À1.0%, 0-2 OD, Stray light: < 0.05% @ 230 nm; Fluorescence Intensity Performance: Reading capabilities: Cuvette or top or bottom of a microplate, Wavelength range: 250-850 nm, Wavelength selection: Monochromators, tunable in 1.0 nm increments, Bandwidth (EX, EM): 9 nm, 15 nm, Sensitivity: < 5 pM fluorescein in 96 wells or cuvette, < 20 pM in 384 wells; Fluorescence Polarization Performance: Wavelength range: 400-750 nm, Wavelength selection: Monochromators, tunable in 1.0 nm increments, Bandwidth (EX, EM): 9 nm, 15 nm, Precision: < 5 mP standard deviation at 1 nM fluorescein in 96 and 384 wells; Time-Resolved Fluorescence Performance: Reading capabilities: Top or bottom of a microplate, Wavelength range: 250-850 nm, Wavelength selection: Monochromators, tunable in 1.0 nm increments, Bandwidth (EX, EM): 9 nm, 15 nm, Precision Data collection: 1-100 flashes, delay of 0-600 ¦Ìsec before read, integration time selectable between 50-1500 ¦Ìsec, Sensitivity: 100 fM europium in 96 or 384 wells with top-read; Luminescence Performance: Reading capabilities: Cuvette or top or bottom of a microplate, Wavelength selection: All wavelengths or with selected wavelengths, Wavelength range: 250-850 nm, Sensitivity: < 2 fg/well lower detection limit for firefly luciferase in 96- and 384-well top read, Cross-talk: < 0.3% in white 96- and 384-well microplates; Typical Read Times (min:seconds)* 96 wells 384 wells: Absorbance 0:18 0:49, Fluorescence Intensity 0:17 0:48, Fluorescence Polarization 0:42 2:03, Time-Resolved Fluorescence 0:17 0:48, Luminescence 2:00 7:00. CDC believes that this requirement is met by only one provider. This procurement will be processed under the authority of FAR 6.302-1 and 6.302-2. Only one responsible source and no other sources will satisfy agency requirements. No solicitation is being issued. Interested persons may identify their interest and capability to respond to this requirement. This procurement is not set-aside for small business. For contractual questions contact Linda M. Young.

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