Dr. Yi Gu heads the Spatial Navigation and Memory Unit (SNMU), which aims to investigate the neural basis pf spatial navigation and memory. Specifically, the experiments in the laboratory plans to use in vivo two-photon imaging approach to measure calcium dynamics of the MEC neurons while observing their structural and molecular properties at the subcellular level. The laboratory will purchase a two-photon laser scanning microscope system to achieve the above measurement. For this microscope system, the laboratory will require two fixed-wavelength (920 nm and 1064 nm) compact femtosecond lasers. The collected data using entire system, including the microscopes and the two lasers, are important to understand the synaptic plasticity of the MEC in spatial learning.

The Spatial Navigation and Memory Unit needs two fixed-wavelength (920 nm and 1064 nm) compact femtosecond lasers to perform research studies focusing on the synaptic plasticity in the medial entorhinal cortex (MEC) during spatial learning. Specifically, fixed wavelength femtosecond lasers at 920 nm and 1064 nm are essential for imaging synaptic surface dynamics of GluA1 using GluA1-SEP and calcium dynamics of the MEC neuron using jRGECO, respectively.

This requirement is expected to be issued on a brand name or equal basis to the Axon 920-1 TPC and Axon 1064-1 TPC.