N02AT70725-C-16 Amendment 1 - This amendment is to post the Brand Name Justification below. Brand Name Justification Project title: Miniature Fluorescent Microscope System Purpose and Objectives: Through market research and consulting with the COR, NCI has established this as a brand name requirement. National Center for Complementary and Integrative Health (NCCIH) has identified a need to purchase a Miniature Microscope System. Due to the specific mice strains we use and the age, the system needs to be light, compact and especially designed to allow for simultaneous and sequential imaging in combination with optogenetic excitation or inhibition within the same brain region to use for functional connectivity and microcircuit analysis as well as phototagging. The Doric miniaturized fluorescence microscope system is the commercially available system that offers the lightest, more compact mini-microscope model that allows for simultaneous calcium imaging and photostimulation or photoinhibition in deep brain structures. This system will be implanted on the head of a mouse that weighs only approx. 30g and that will be freely behaving and tested for pain sensitivity. The heavier and bulkier the apparatus, the more uncomfortable, unstable and unnatural it is for the mouse, which will confound the interpretation of our results. Due to these dependencies, Miniature Microscope System is currently the only system that achieves these characteristics. Proposed manufacturers/ Original Equipment Manufacturer (OEM)s: Doric Lenses Inc. 357 Franquet Quebec , QC CANADA, G1P 4N7 Specifications: Miniature Microscope System The vendor and its business partners shall deliver this system to NCCIH. The system requirements are, at a minimum: (1) OTPG_4 Optogenetics TTL Pulse Generator - 4 channels BNC Cables are not inc included (1) FMD_L Fluorescence Microscope Driver Included: Ethernet cable 2m, M8 cable 1m, USB memory stick with software (Doric Neuroscience Studio) and power cord, all countries (3) SL Cable RF BNC / BNC - 50 Ohm - 0.6m (1) Ce:YAG_612/069_LED/465 Ce:Yag & Blue Fiber Light Source (1) MFP_200/230/LWMJ-0.48_1m_FC-FC Mono Fiberoptic Patchcord (1) FMH Fluorescence Microscope Holder (1) CLAMP_FMH Clamp for Fluorescence Microscope Holder (1) AHRJ-OE_PT_AH_12_HDMI Assisted Optical & Electrical rotary joint, pigtailed (1) ADAPTER_FC FC/FC Mating Adapter (1) MFP_200/230/LWMJ-0.48_0.8m_FC-CM3 Mono Fiberoptic Patchcord (3) MFP_200/230/900-0.48_0.8m_FC-CM3 Mono Fiberoptic Patchcord (1) DSMB-L Dummy Snap-In Microscope Body-L (1) OSFM_L_UFGJ_1000_458/604 GCamp6 NpHR3 Body-L Fiberglass jacket (5) SICL_V_500_5.66_80 Snap-in Imaging Cannula, Model L-VFARS_L Focus Adjustment Ring Set (1) FMST Fluorescence Microscope Snaping Tool (1) BTC_CO : Behavior Tracking Camera system Color (1) 5-port Gigabit PoE+ Switch TRENDnet TPE-TG50g with 1 ethernet cable (1) Shipping and Handling Delivery: Contractor shall deliver the equipment within 60 days after the award to: NCCIH, Bethesda, Maryland 20892. Contractor that receives the award will be provided with the complete mailing address and point of contact. Upon delivery, contractor must notify Yarimar Carrasquillo to schedule delivery date and time.

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