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1.0 SCOPE OF WORK: This Statement of Work (SOW) defines the procurement of the technical expertise and support services necessary to refine animal models of military relevant brain injury by better understanding the co-morbidities during the sub-acute and chronic timeframe after injury. This work supports the mission of the Brain Trauma, Neuroprotection and Neurorestoration (BTNN) Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research (WRAIR).
2.0 BACKGROUND: The mission of the Walter Reed Army Institute of Research (WRAIR) is to conduct biomedical research that is responsive to Department of Defense and U.S. Army requirements and delivers lifesaving products including knowledge, technology, and medical materiel that sustain the combat effectiveness of the war fighter. Brain Trauma Neuroprotection and Neurorestoration (BTNN) Branch, Center for Military Psychiatry and Neuroscience, of the WRAIR conducts preclinical research of mild-severe traumatic brain injury (TBI), specifically the penetrating ballistic-type TBI and closed head impact concussion for the U.S. Army Medical Research and Materiel Command (USAMRMC). Research specializes in "polytrauma", accounting for the impact of hemorrhagic shock and failure to oxygenate and/or ventilate on the progression brain injury.
This research collaboration will evaluate a novel neurotherapeutic resuscitation strategy for treating TBI in the event of hemorrhagic shock during the pre-hospital phase. The findings will be the basis for future preclinical studies with delayed/long-term treatments and will provide important knowledge for future clinical studies. The research will provide insight leading to improvements in clinical practice guidelines to optimize resuscitation approaches for patients with TBI (i.e. approaches to optimize cerebral perfusion and brain salvage). Successful translation of solutions generated from the research will improve stabilization and salvage of neurologic injuries at all echelons of care.