The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the area of mathematical systems of representation and analysis as applied to complex phenomena. Advances in computational capabilities and measurement technologies have rapidly expanded the volume, scale, and variety of data across many complex scientific and engineering fields. However, without tools to unify principles, results, models, and data into a single computational representation, it is difficult to relate individual datasets to the larger body of knowledge at scale. The SIMPLEX program will develop unified mathematical frameworks and tools for the context-aware analysis of scientific data to facilitate big hypothesis generation and accelerate discovery. In order to validate the representations and tools, SIMPLEX will also develop practical implementations for multiple scientific and engineering use cases. Examples of domains of interest include, but are not limited to, neuroscience, gene-protein disease networks, materials science, climate science, autonomous systems, and cyber-physical systems. The goal of SIMPLEX is to create domain-agnostic mathematical formalisms to capture functional relationships across multi-scale heterogeneous data and forms of knowledge. SIMPLEX will enable investigation of scientific questions through formal mathematical techniques and data-driven interactive queries to complement the time-consuming and often insufficient pursuit of published literature.

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